As many as 12 players have question marks beside their names with regard to whether or not they will be able to take part in the Tigers clash and arriving just a few days after a brutal battle at Preston North End on Friday evening, Danny Rohl has a cut-down squad to choose from.
Will Vaulks and Akin Famewo are the latest injury doubts after they both hobbled out at Deepdale with hamstring concerns, while George Byers may by suspended with no official word on whether Wednesday have appealed the red card he was shown late on in the 1-0 win.
Here's a whistle-stop run-down of all the Wednesday 'maybes' and 'definitely nots' heading into tonight's televised Hillsborough clash.
1. George Byers (Suspended)
There's been no official word on whether or not Wednesday have appealed the red card shown to Byers at Preston for some afters following a tackle late on in their impressive win. If it is upheld as expected, Hull will be the first of a three-match ban. Photo: Jess Hornby
2. Akin Famewo (Hamstring)
Famewo hobbled out of the first half of the Deepdale win, with his manager later suggesting it was down to a hamstring issue. It's too early to know of any timescale. Photo: Steve Ellis
3. Will Vaulks (Hamstring)
Another casualty of the Preston win, Vaulks has been in fine form recently and will be missed if his issue proves to be a tricky one. Photo: Ashley Allen
4. Bambo Diaby (Suspended)
The big defender saw red after the final whistle of Wednesday's Boxing Day defeat at Coventry City for an off-the-ball incident with Liam Kitching. Hull will be the second of a three-match ban.