Garry Monk's side begin the 2020/21 campaign in tough circumstances after being charged by the EFL in July – resulting in a points deduction.
But do the bookies believe Wednesday can avoid relegation? Scroll and click through the pages to find out:
1. Brentford
Odds to be relegated from the Championship: 66/1 Photo: Mike Hewitt
2. Norwich City
Odds to be relegated from the Championship: 50/1 Photo: Julian Finney
3. Watford
Odds to be relegated from the Championship: 40/1 Photo: RUI VIEIRA
4. Nottingham Forest
Odds to be relegated from the Championship: 25/1 Photo: Catherine Ivill