Here we take a look back at the previous nine clashes between the two sides.
1. February 2019, Wednesday 2-0 Bees
Owls striker Steven Fletcher slots home the first of his two goals in Wednesday's 2-0 win over the Bees at Hillsborough. Photo: Steve Ellis
2. August 2018, Brentford 2-0 Wednesday
Striker Neal Maupay sends Owls 'keeper Cameron Dawson the wrong way from the spot to give the Bees the lead. Ollie Watkins netted a second to give the home side all three points in a 2-0 win. Photo: Steve Ellis
3. December 2017, Brentford 2-0 Wednesday
Owls defender Jack Hunt battles it out with Bees goalscorer Florian Jozefzoon during a 2-0 defeat for Wednesday at Griffin Park in December 2017. Photo: Steve Ellis
4. September 2017, Wednesday 2-1 Brentford
Gary Hooper is all smiles after equalising for Wednesday in their eventual 2-1 win over the Bees at Hillsborough in September 2017. Ross Wallace was also on target in the win. Photo: Steve Eliis