Video: Sheffield Wednesday dealt yet another injury blow - season over for three more players
Morgan Fox came off after nine minutes of the 3-1 win over Sunderland at the Stadium of Light and he has been ruled out for the remainder of the campaign with a hamstring injury.
And Luhukay said that Sam Hutchinson, who came off at half time in the victory over Preston, has also been told that his season is over.
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Hide AdHutchinson had only just returned to the side before the international break but picked up an ankle injury on Friday and was told by doctors that his recovery would be six to eight weeks.
"I've had advice from the doctor and he said six to eight weeks, so he cannot play anymore this season," said Luhukay.
"For Sam personally, it is very, very difficult. He is a very good player but he has had a lot of injuries. For him personally it was a shock when he got the diagnosis from the doctor."
And Gary Hooper, who has been out since December, visited a specialist last week and he won't play again this season either.
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Hide AdLuhukay said: "(The news) was not negative but we have now with Morgan and Sam ten players who won't come back this season and Gary is one of them."
Daniel Pudil missed the trip to the north east but Luhukay said that he should be available for the weekend visit of Fulham.
"I spoke with Daniel yesterday, he didn't feel good. He was afraid that something was wrong with his hamstring. He felt he wasn't 100%, and when that is the case we won't risk the player. So we gave him a rest and in the next days we hope he can play on Saturday against Fulham."